MHC Class II molecules are open only on a few specialized cell types including s s and all of which are professional (APCs).
The peptides presented by categorise II molecules are derived from extracellular proteins (not cytosolic as in class I); hence the MHC categorise II-dependent pathway of antigen presentation is called the
Loading of class II molecules must still become inside the cell; extracellular proteins are digested in s and bound by the class II MHC molecule prior to the molecule's migration to the plasma membrane.
desire MHC categorise I molecules class II molecules are also s but in this inspect be of two homologous peptides an α and β chain both of which are encoded in the MHC.
Because the peptide-binding incise of MHC categorise II molecules is open at both ends while the corresponding groove on class I molecules is closed at each end the peptides presented by MHC class II molecules are longer generally between 15 and 24 residues desire.
Because categorise II MHC is loaded with extracellular proteins it is mainly concerned with presentation of extracellular pathogens (for example bacteria that might be infecting a wound or the blood). categorise II molecules act exclusively with
s). The then help to initiate an allot immune response which may include localized and swelling due to recruitment of phagocytes or may bring about to a full-force antibody immune response due to activation of B cells.
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